In this study, the aim was to find out the prevalence of ABO & Rhesus blood groups in a group of persons at two places in North India & one place in Northeast India. In this study, the results showed that the prevalence of different blood groups among one group of 2140 patients evaluated at RH & WCMSRH in North India was approximately: B 35%, O 32%, A 23% & AB 10%. The results also showed that the prevalence of different blood groups among one group of 205 students evaluated at JMCH in Northeast India was approximately: O 35.5%, B 28%, A 27.5% & AB 9%. Thus, it is concluded that in the present studies at RH & WCMSRH in North India, B gene was most common, while in JMCH study in Northeast India, O gene occurred most frequently. The blood group A was 3rd most common blood group & the blood group AB was infrequent in all the 3 studies in India. The Rh negatives were about 07% in North India & about 04% in Northeast India.