Objectives: The aim of this study is to compare the effect of artificial saliva on flexural strength of three commercially available denture base acrylic resins. Methods: In this study three commercially available heat cure denture base resins namely Trevalon, Trevalon-Hi and Pyrax Acryl-Hi were taken. The artificial saliva was prepared in one of our laboratory and the samples were immersed in artificial saliva in order to simulate oral environment. The time dependent changes in the flexural strength of acrylic resins was evaluated and compared with the samples soaked in artificial saliva. Results: A total of 84 samples (28 samples of each type) were made. According to the mean value, the flexural strength was in following order: Trecvalon-Hi; Pyrax Acryl-Hi and Trevalon. The flexural strength decreases with time and after soaking in saliva. Conclusion: PYRAX Acryl-Hi possesses good strength and aesthetics and offers better treatment options as the results are concerned. Since it is manufactured in India it is free from import-export charges. Hence it is relatively economical.