Membrane proteins have a pivotal role in cell biology. They are involved in supervising the cellular interactions and maintaining stability of the cell structure. Astrotactin-2 is a perfor in like protein, which has a crucial role in many neuro developmental brain disorders such as autism spectrum disorder, bipolar disorder, schizophrenia etc. Since transmembrane proteins are large in size, it is necessary to precisely orient the protein and thus coarse-grained simulation serves as the best option for computational studies of MPs. Coarse-grained models have been successfully used in studying proteins.Here in this study, MARTINI force field was used to run the coarse-grained simulation of ASTN-2.