A closed nine-stepped cycle of proton conductance unifies cellular bioenergetics and systemic physiology

For more than half a century, proton flow in biology has been treated as a partial process confined to mitochondria. Here we describe a closed nine-stepped cycle of proton conductance that completes this picture by uniting intracellular bioenergetics with systemic physiology. The Ambaga Closed 9-Stepped Cycle tracks every proton and electron from food-derived hydrogen through mitochondrial redox reactions, serum buffering, erythrocyte carbonic exchange, and pulmonary - tissue oxygen substitution, returning the same protons to the next metabolic turn. This continuity fulfills complete proton bookkeeping and integrates the chemiosmotic theory of Mitchell, the binding-change model of Boyer, and the ATP-synthase structure of Walker into a single self-consistent system. The cycle predicts measurable redox-potential transitions (alpha,betta, gamma membrane states) and isotopic proton conservation across compartments. These findings establish a unified framework for energy metabolism, oxygen transport, and soft-drug activation, redefining the proton as the central quantized currency of life.