The effect of cadmium on the biochemical and haematological parameters of Labeo rohita were observed, after exposure to sublethal concentrations of cadmium (51.82 µg/l) for a period of 24, 48, 72 and 96 hrs. The number of white blood cells (WBC) and glucose levels were increased. The numbers of red blood cells (RBC), haemoglobin content, haematocrit, concentration was significantly higher (p>0.05) in the experimental group, compared with the control group. The above results of examination of the blood parameters indicate a marked physiological effect of cadmium in fish.