Cheilitis granulomatosa - An enigma to clinicians

Cheilitis granulomatosa is a chronic swelling of the lip due to granulomatous inflammation. It is a rare inflammatory disorder first described by Miescher in 1945. It is a monosymptomatic form or an incomplete variant of Melkersson-Rosenthal syndrome; a triad of recurrent orofacial edema, recurrent facial nerve palsy and fissuring of the tongue. As the etiology remains unknown, treatment of cheilitis granulomatosa is very challenging. We here by present a case of cheilitis granulomatosa in a 42-year-old female patient with swelling of lower lip for last eight years. This case highlights the importance of extensive investigations in the diagnosis of this lesion as the findings mimic many other granulomatous conditions.