Cemento-ossifying fibromas are rare fibro-osseous benign neoplasms that are seen in the jaws. They are included in the group of mesodermal odontogenic tumors and commonly present as a progressively growing lesion that might attain great size with resultant deformity, if not treated. Cemento-OF (COF) is a benign neoplasm that arises from the periodontal membrane which contains multipotential cells that are capable of forming cementum, lamellar bone and fibrous tissue. These tumors occur in the third and fourth decades of life, with predilection for women, predominantly occurring in the premolar/molar region of the mandible. A case of cemento-ossifying fibroma involving the right side of mandible is described in a 38 year-old male patient, with description of clinical, radiographic, and histologic features.