Dental caries is not a life menacing disease, so it is under progress with no active steps been taken for its total eradication. Active and passive immunization strategies have been developed which target key elements in the molecular pathogenesis of mutans streptococci. Along with established methods of caries prevention, caries vaccines have the potential of making a highly valuable contribution to disease control. Progress towards practical vaccine development requires evaluation of candidate vaccines in clinical trials. Promising strategies of passive immunization also require further clinical evaluation. The present review gives an overview of the current developments, drawbacks and potential of revolutionary caries management.
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