Objective: To assess Burden of road traffic accident among victims admitted to Dessie Referral hospita at Dessie town, South Wollo Zone, Ethiopia 2018 G.C. Results: A total of 306 injury victim medical records were considered and of which 270 were actually included in this study. Of which 51(18.9%) were due to road traffic accidents. The male to female ratio was 2:1. The highest number 177(66%) of victims who came to facilities were between 25-40 years of age. Concerning the place where the accidents happened, major accidents 258(95.6%) was occurred on the streets. Out of the total road traffic injury, most of them were passengers 190(70.4%).