A cross sectional descriptive study was conducted to assess the knowledge of primi mothers regarding newer vaccines, a total of 30 primi mothers were selected by purposive sampling techniqueatSuramangalam Maternity center, Salem. Interview schedule was used to collect the data and collected data was analyzed by descriptive statistics.Major finding of the this study shows that majority of the mothers were 20-25 years of age highest percentage of the mothers had high school education, majority were private workers, highest of the family were in the economic group of Rs. 5000-10,000 most of the mothers were in nuclear family. Over all primimothers had average knowledge on newer vaccine.