In the present investigation immunomodulatory activity was studied for the plant Borreria articularis leaf extract using rat model. Borreria articularis is an Indian medicinal system and has been used in ayurvedic preparation for the treatment of various ailments throughout the countries. Immunomodulation is a process, which alters the immune system of an organism by inferring with its function. Cyclophosphamide was used as a standard immunosuppressant agent. Sodium Carboxy Methyl Cellulose (SCMC) is being a non-immunogenic and tolerogenic substance, it has been considered as control group. In order to know their effectiveness on humoral antibody production against SRBC, haemagglutination and delayed type hypersensitivity (DTH) were studied. The results of immunomodulatory activity for 7 day pretreatment and 15 days post treatment are tabulated respectively. The antibody titer has been measured using haemagglutination (HA) test and DTH, it has been increasing in proportionate to the concentration of extract dose up to 1200 mg/kg.
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