Analysis on effectiveness of selected herbal extracts in cholecystitis prevention and treatment in rats

A gallstone is a crystallineconcretion formed within the gallbladder by accretion of bile components. These calculi are formed in the gallbladder, but may pass distally into other parts of the biliary tract such as the cystic duct, common bile duct, pancreatic duct or the ampulla of Vater. Presence of gallstones in other parts of the biliary tract can cause obstruction of the bile ducts, which can lead to serious conditions such as ascending cholangitis or pancreatitis. Either of these two conditions can be life-threatening, and are therefore considered to be medical emergencies. Thirty-two rats were divided into an experimental and a control group, with 16 hamsters in each group. Fenofibrate, cholestyramine and a low protein and high cellulose diet will be given for 6 weeks to induce the formation of pigment gallstones in the experimental group and a normal diet was given to the control group. Ursodiol will be given to control treatment group and plant extract such as leaves of Borreriaarticularis, Peppermint leaf extract and Ginger root extract has been given separately to test treatment group. Liver function tests, Lipid profile, renal function tests has been assessed and statistically interpreted after 6 weeks. All the values are statistically treated.